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KMID : 1123920030170051264
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 5 p.1264 ~ p.1269
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Inhibitory effects of the Juglans sinensis Walnut Ethanol Extract on Carbon Tetrachloride-induced hepatic fibrosis in Rats
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Jang Seon-Il
Lim Chang-Kyung
Ryu Jin-Duk
Kim Hui-Soo
Yun Young-Gab
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Abstract
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The inhibitory effects of the Juglans sinensis walnut ethanol extract (JSWE) on carbon tetrachloide (CCl₄)-induced fibrosis, serum transaminases (GOT and GTP), hepatic glutathione (GSH), serum pro-inflammatory cytokines (IL-1β and IL-6) were investigated in rats. JSWE significantly inhibited on CCl₄-induced fibrosis in dose-dependent manner. Moreover, JSWE significantly inhibited on the serum levels of GOT, GTP, IL-1β, and IL-6 in dose-dependent manner in CCl₄-induced fibrosis rat. However, JSWE markedly increased the production of hepatic GSH in a dose-dependent manner. These results show that JSWE may explain some known biological activities of Juglans sinensis walnut including their anti-fibrotic and anti-inflammatory effects, and is of considerable benefit in the treatment for live diseases.
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KEYWORD
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Juglans sinensis Walnut, Fibrosis, Transaminases, Glutathione, Pro-inflammatory Cytokines
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